CC chemokine ligand 2 (CCL2) promotes prostate cancer tumorigenesis and metastasis.

@article{Zhang2010CCCL,
  title={CC chemokine ligand 2 (CCL2) promotes prostate cancer tumorigenesis and metastasis.},
  author={Jian Zhang and Lalit K. Patel and Kenneth J. Pienta},
  journal={Cytokine & growth factor reviews},
  year={2010},
  volume={21 1},
  pages={41-8}
}
CCL2 is a chemokine known to recruit monocytes and macrophages to sites of inflammation. A growing body of research suggests CCL2 is progressively overexpressed in tumor beds and may play a role in the clinical progression of solid tumors. Cancer cells derived from several solid tumor types demonstrate functional receptors for CCL2, suggesting this chemokine may achieve tumorigenicity through direct effects on malignant cells; however, a variety of normal host cells that co-exist with cancer in… CONTINUE READING