CBS9106 is a novel reversible oral CRM1 inhibitor with CRM1 degrading activity.

  title={CBS9106 is a novel reversible oral CRM1 inhibitor with CRM1 degrading activity.},
  author={Keiichi Sakakibara and Naoya Saito and Takuji Sato and Atsushi Suzuki and Yoko Hasegawa and Jonathan M Friedman and Donald Kufe and Daniel D Vonhoff and Tadahiko Iwami and Takumi Kawabe},
  volume={118 14},
CRM1 plays an important role in the nuclear export of cargo proteins bearing nuclear exporting signal sequences. Leptomycin B (LMB), a well-known CRM1 inhibitor, possesses strong antitumor properties. However, its toxicity prevents it from being clinically useful. In this study, we demonstrate that a novel compound, CBS9106, inhibits CRM1-dependent nuclear export, causing arrest of the cell cycle and inducing apoptosis in a time- and dose-dependent manner for a broad spectrum of cancer cells… CONTINUE READING


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