CBP/p300: intramolecular and intermolecular regulations

  title={CBP/p300: intramolecular and intermolecular regulations},
  author={Yongming Xue and Hong Wen and Xiaobing Shi},
  journal={Frontiers in Biology},
CREB binding protein (CBP) and its close paralogue p300 are transcriptional coactivators with intrinsic acetyltransferase activity. Both CBP/p300 play critical roles in development and diseases. The enzymatic and biological functions of CBP/p300 are tightly regulated by themselves and by external factors. However, a comprehensive up-to-date review of the intramolecular and intermolecular regulations is lacking. To summarize the molecular mechanisms regulating CBP/p300s functions. A systematic… CONTINUE READING


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