• Corpus ID: 28780766

CBNAAT : a Novel Diagnostic Tool For Rapid And Specific Detection Of Mycobacterium Tuberculosis In Pulmonary Samples

@inproceedings{Sowjanya2015CBNAATA,
  title={CBNAAT : a Novel Diagnostic Tool For Rapid And Specific Detection Of Mycobacterium Tuberculosis In Pulmonary Samples},
  author={D. S. Sowjanya and Ganeswar Behera and V. V. Ramana Reddy and J. V. Praveen},
  year={2015}
}
Mycobacterium tuberculosis remains to be one of the most significant causes of death from an infectious agent. Rapid diagnosis of tuberculosis and detection of Rifampicin (RIF) resistance are essential for effective disease management. CBNAAT (Cartridge Based Nucliec Acid Amplification Test) also known as Gene Xpert MTB/RIF assay is a novel integrated diagnostic device for the diagnosis of tuberculosis and rapid detection of RIF resistance in clinical specimens. We determined the performance of… 

Figures and Tables from this paper

Cepheid GeneXpert Mycobacterium tuberculosis/Rifampicin assay for the rapid detection of Mycobacterium tuberculosis and identification of Rifampicin resistance

The MTB/RIF test is a simple and rapid method, and staff with adequate training can perform this test with minimal laboratory setup, and offers high potential for the diagnosis of TB and RIF resistance.

Role of cartridge-based nucleic acid amplification test for early diagnosis of pulmonary tuberculosis

CBNAAT helps in increased case detection in lesser time to diagnose pulmonary tuberculosis as compared to conventional sputum microscopy and detects the rifampicin resistance with high specificity to start early treatment.

Cartridge-based nucleic acid amplification test: a novel rapid diagnostic tool to study the burden of tuberculosis from a tertiary care hospital

The GeneXpert polymerase chain reaction test (known in India as CBNAAT) and is capable of diagnosing TB and rifampicin resistance within 2 h) is a promising tool and should be used as a near-point-of-care test.

Role of CBNAAT for Early Diagnosis of Pulmonary Tuberculosis and Percentage of Rifampicin Resistance among the Patients Admitted in Government General Hospital, Siddipet

CBNAAT detects pulmonary TB with greater efficacy than sputum microscopy also helping in early diagnosis in less than 2 hours and can be used for screening for MDR-TB so that early therapy can be started thus decreasing the incidence of M DR-TB.

Roleof Cartridge-Based Nucleic Acid Amplification Test (Cbnaat) For Early Diagnosis of Tuberculosis: A Retrospective Study

CBNAAT is an important diagnostic modality especially in sputum negative patients for early diagnosis and treatment in lesser time as compared to conventional sputUM microscopy and it detects the rifampicin resistance with high specificity to start early treatment.

Role of cartridge -based nucleic acid amplification test (CBNAAT) for early diagnosis of pulmonary tuberculosis in HIV

CBNAAT is a rapid, reliable tool with least bio-safety concern and requires minimally trained staff, is best alternative to conventional methods of tubercular diagnosis and detects rifampicin resistance simultaneously within 2 hours.

Role of Cartridge Based Nucleic Acid Amplification Testing in Diagnosis of Extrapulmonary Tuberculosis- Experience from a Teaching Institution in Eastern India

CBNAAT adds significantly to the diagnostic yield of EPTB in comparison to conventional methods, but its sensitivity varies in different forms of extrapulmonary tuberculosis.

A study on prevalence of rifampicin resistance by Gene Xpert with clinico-radiological correlation in previously treated pulmonary tuberculosis patients

The overall prevalence of rifampicin resistance is 22.64% among previously treated pulmonary tuberculosis, and the failure case is significantly associated with rifampsic in resistance.

PREVALENCE OF POSITIVITY OF CBNAAT IN PULMONARY TUBERCULOSIS

  • Rakesh Bhatnagar
  • Medicine
    International Journal of Medical and Biomedical Studies
  • 2022
CBNAAT detects pulmonary TB with greater efficacy than sputum microscopy also helping in early diagnosis in less than 2 hours and can be used for screening for MDR-TB so that early therapy can be started thus decreasing the incidence of M DR-TB.

Is Cartridge Based Nucleic Acid Amplification Test (CBNAAT) Better Than Conventional Tests in Diagnosing Childhood Tuberculosis? Evidence from a Tertiary Care Hospital in Eastern India

CBNAAT assay is highly sensitive and specific to detect tuberculosis rapidly comparing to the traditional tests with rifampicin resistance associated with mutation of rpoB gene in a single test, and helps in avoiding injudicious use of anti-tubercular drugs.

References

SHOWING 1-9 OF 9 REFERENCES

Diagnosing pulmonary tuberculosis with the Xpert MTB/RIF test.

The Xpert MTB/RIF assay has the potential to bring standardized, sensitive and very specific diagnostic testing for both TB and drug resistance to universal-access point-of-care settings, provided that they will be able to afford it.

Rapid Detection of Mycobacterium tuberculosis and Rifampin Resistance by Use of On-Demand, Near-Patient Technology

The first analysis of the Cepheid Gene Xpert System's MTB/RIF assay is developed and performed, an integrated hands-free sputum-processing and real-time PCR system with rapid on-demand, near-patient technology, to simultaneously detect M. tuberculosis and rifampin resistance.

Evaluation of the Analytical Performance of the Xpert MTB/RIF Assay

ABSTRACT We performed the first studies of analytic sensitivity, analytic specificity, and dynamic range for the new Xpert MTB/RIF assay, a nucleic acid amplification-based diagnostic system that

Updated guidelines for the use of nucleic acid amplification tests in the diagnosis of tuberculosis.

CDC recommends that NAA testing be performed on at least one respiratory specimen from each patient with signs and symptoms of pulmonary TB for whom a diagnosis of TB is being considered but has not yet been established, and for whom the test result would alter case management or TB control activities, such as contact investigations.

Molecular mechanisms of multiple drug resistance in clinical isolates of Mycobacterium tuberculosis.

Of the 20 multiply resistant strains with reduced sensitivity to streptomycin, rifampin, and isoniazid, 11 had mutations in genetic markers associated with resistance to each of these three drugs.

Are Three Sputum Acid-Fast Bacillus Smears Necessary for Discontinuing Tuberculosis Isolation?

The negative predictive value of the smear increased by only 0.2% on days 2 and 3 each, indicating that in low-prevalence populations, there is limited value in requiring three negative sputum AFB smears before discontinuing tuberculosis isolation.

Anti - tuberculosis resistance in the world : fourth global report

  • Global Tuberculosis Control
  • 2010

National Tuberculosis Center and California Department of Public Health, 2008: DrugResistant Tuberculosis, a Survival Guide for Clinicians, Second Edition

  • 2008