CBL mutations do not frequently occur in paediatric acute myeloid leukaemia.

@article{Coenen2012CBLMD,
  title={CBL mutations do not frequently occur in paediatric acute myeloid leukaemia.},
  author={Eva A. Coenen and Emma M. C. Driessen and Christian Michel Zwaan and Jan Star{\'y} and Andr{\'e} Baruchel and Valerie de Haas and Eveline de Bont and Dirk Reinhardt and Gertjan J L Kaspers and Susan T J C M Arentsen-Peters and Claus Meyer and Rolf Marschalek and Rob Pieters and Ronald W. Stam and Marry M van den Heuvel-Eibrink},
  journal={British journal of haematology},
  year={2012},
  volume={159 5},
  pages={577-84}
}
RAS-pathway mutations, causing a proliferative advantage, occur in acute myeloid leukaemia (AML) and MLL-rearranged leukaemia. Recently, mutations in the Casitas B lineage lymphoma (CBL) gene were reported to be involved in RAS-pathway activation in various myeloid malignancies, but their role in paediatric AML is still unknown. We performed mutation analysis of 283 newly diagnosed and 33 relapsed paediatric AML cases. Only two mutant cases (0·7%) were identified in the newly diagnosed… CONTINUE READING