CBFB/MYH11 fusion in a patient with AML-M4Eo and cytogenetically normal chromosomes 16.

@article{PircDanoewinata2000CBFBMYH11FI,
  title={CBFB/MYH11 fusion in a patient with AML-M4Eo and cytogenetically normal chromosomes 16.},
  author={Hendrati Pirc-Danoewinata and Hans G. Dauwerse and Margit Koenig and Ilse Chudoba and Margit Mitterbauer and Ulrich Jaeger and Martijn H. Breuning and Oskar Arthur Haas},
  journal={Genes, chromosomes & cancer},
  year={2000},
  volume={29 2},
  pages={186-91}
}
We present a unique case of acute myeloid leukemia M4Eo (AML-M4Eo) with a CBFB/MYH11 fusion transcript and a trisomy 22, but in whom cytogenetic analyses did not disclose an inv(16). Fluorescence in situ hybridization (FISH) analysis with chromosome arm-specific painting probes as well as with the c40 and c36 cosmids also revealed no evidence for an inv(16), whereas the application of locus-specific probes confirmed the presence of a masked inv(16). The results of our comprehensive FISH… CONTINUE READING

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