CB2 receptor‐mediated antihyperalgesia: possible direct involvement of neural mechanisms

@article{Beltramo2006CB2RA,
  title={CB2 receptor‐mediated antihyperalgesia: possible direct involvement of neural mechanisms},
  author={M. Beltramo and N. Bernardini and R. Bertorelli and M. Campanella and E. Nicolussi and S. Fredduzzi and A. Reggiani},
  journal={European Journal of Neuroscience},
  year={2006},
  volume={23}
}
  • M. Beltramo, N. Bernardini, +4 authors A. Reggiani
  • Published 2006
  • Chemistry, Medicine
  • European Journal of Neuroscience
  • In mouse the cannabinoid receptor 2 (CB2) agonists L768242 and (+)‐AM1241, at doses of 30 mg/kg i.p. and 1 and 3 mg/kg i.v., respectively, reduced the second phase of nocifensive behaviors elicited by formalin intraplantar injection. This effect was counteracted by the selective CB2 antagonist SR144528 (1 mg/kg i.p.). In rat (+)‐AM1241 (3 and 6 mg/kg i.v.) and L768242 (30 mg/kg i.p.) reduced allodynia elicited by L5–L6 spinal nerve ligation. SR144528 reverted these effects, supporting a CB2… CONTINUE READING
    254 Citations
    Involvement of central cannabinoid CB2 receptor in reducing mechanical allodynia in a mouse model of neuropathic pain.
    • 74
    • Highly Influenced
    Activation of cannabinoid receptor 2 inhibits experimental cystitis.
    • 25
    • PDF
    Cannabinoid CB2 Agonist GW405833 Suppresses Inflammatory and Neuropathic Pain through a CB1 Mechanism that is Independent of CB2 Receptors in Mice
    • 14
    • Highly Influenced
    • PDF

    References

    SHOWING 1-10 OF 46 REFERENCES
    CB1 and CB2 cannabinoid receptors are implicated in inflammatory pain
    • 203
    • Highly Influential
    Inhibitory effects of CB1 and CB2 receptor agonists on responses of DRG neurons and dorsal horn neurons in neuropathic rats
    • 137
    • Highly Influential
    Inhibition of Inflammatory Hyperalgesia by Activation of Peripheral CB2 Cannabinoid Receptors
    • 211
    • Highly Influential
    • PDF
    CB2 cannabinoid receptor activation produces antinociception by stimulating peripheral release of endogenous opioids.
    • M. Ibrahim, F. Porreca, +8 authors T. Malan
    • Chemistry, Medicine
    • Proceedings of the National Academy of Sciences of the United States of America
    • 2005
    • 449
    • Highly Influential
    • PDF
    Activation of CB2 cannabinoid receptors by AM1241 inhibits experimental neuropathic pain: Pain inhibition by receptors not present in the CNS
    • M. Ibrahim, H. Deng, +8 authors T. Malan
    • Chemistry, Medicine
    • Proceedings of the National Academy of Sciences of the United States of America
    • 2003
    • 428
    • PDF
    Actions of cannabinoid receptor ligands on rat cultured sensory neurones: implications for antinociception
    • 172
    Induction of CB2 receptor expression in the rat spinal cord of neuropathic but not inflammatory chronic pain models
    • 349
    • Highly Influential
    Increased mortality, hypoactivity, and hypoalgesia in cannabinoid CB1 receptor knockout mice.
    • 987
    • PDF