CB2 receptor‐mediated antihyperalgesia: possible direct involvement of neural mechanisms

@article{Beltramo2006CB2RA,
  title={CB2 receptor‐mediated antihyperalgesia: possible direct involvement of neural mechanisms},
  author={Massimiliano Beltramo and Nadia Bernardini and Rosalia Bertorelli and Marilena Campanella and Elisa Nicolussi and Silva Fredduzzi and Angelo Reggiani},
  journal={European Journal of Neuroscience},
  year={2006},
  volume={23}
}
In mouse the cannabinoid receptor 2 (CB2) agonists L768242 and (+)‐AM1241, at doses of 30 mg/kg i.p. and 1 and 3 mg/kg i.v., respectively, reduced the second phase of nocifensive behaviors elicited by formalin intraplantar injection. This effect was counteracted by the selective CB2 antagonist SR144528 (1 mg/kg i.p.). In rat (+)‐AM1241 (3 and 6 mg/kg i.v.) and L768242 (30 mg/kg i.p.) reduced allodynia elicited by L5–L6 spinal nerve ligation. SR144528 reverted these effects, supporting a CB2… 

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