CB2 receptor‐mediated antihyperalgesia: possible direct involvement of neural mechanisms

  title={CB2 receptor‐mediated antihyperalgesia: possible direct involvement of neural mechanisms},
  author={M. Beltramo and N. Bernardini and R. Bertorelli and M. Campanella and E. Nicolussi and S. Fredduzzi and A. Reggiani},
  journal={European Journal of Neuroscience},
  • M. Beltramo, N. Bernardini, +4 authors A. Reggiani
  • Published 2006
  • Medicine, Biology
  • European Journal of Neuroscience
  • In mouse the cannabinoid receptor 2 (CB2) agonists L768242 and (+)‐AM1241, at doses of 30 mg/kg i.p. and 1 and 3 mg/kg i.v., respectively, reduced the second phase of nocifensive behaviors elicited by formalin intraplantar injection. This effect was counteracted by the selective CB2 antagonist SR144528 (1 mg/kg i.p.). In rat (+)‐AM1241 (3 and 6 mg/kg i.v.) and L768242 (30 mg/kg i.p.) reduced allodynia elicited by L5–L6 spinal nerve ligation. SR144528 reverted these effects, supporting a CB2… CONTINUE READING
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