CB2 cannabinoid receptor agonist JWH-015 modulates human monocyte migration through defined intracellular signaling pathways.

@article{Montecucco2008CB2CR,
  title={CB2 cannabinoid receptor agonist JWH-015 modulates human monocyte migration through defined intracellular signaling pathways.},
  author={Fabrizio Montecucco and Fabienne Burger and François Mach and Sabine Steffens},
  journal={American journal of physiology. Heart and circulatory physiology},
  year={2008},
  volume={294 3},
  pages={
          H1145-55
        }
}
Recruitment of leukocytes to inflammatory sites is crucial in the pathogenesis of chronic inflammatory diseases. The aim of this study was to investigate if activation of CB2 cannabinoid receptors would modulate the chemotactic response of human monocytes. Human monocytes treated with the CB2 agonist JWH-015 for 12-18 h showed significantly reduced migration to chemokines CCL2 and CCL3, associated with reduced mRNA and surface expression of their receptors CCR2 and CCR1. The induction of ICAM-1… 

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