CB1 receptors modulate the intake of a sweetened-fat diet in response to mu-opioid receptor stimulation of the nucleus accumbens

@article{Skelly2010CB1RM,
  title={CB1 receptors modulate the intake of a sweetened-fat diet in response to mu-opioid receptor stimulation of the nucleus accumbens},
  author={Mary Jane Skelly and Elizabeth G Guy and Allyn C. Howlett and Wayne Ethan Pratt},
  journal={Pharmacology Biochemistry and Behavior},
  year={2010},
  volume={97},
  pages={144-151}
}
Previous research has demonstrated that concurrent systemic administration of CB(1) cannabinoid and mu-opioid receptor agonists increases feeding in rats. However, the possible neural loci of this cooperative effect have yet to be identified. These studies tested whether the nucleus accumbens shell may be one site of the interactive effects of opioid and cannabinoid ligands on feeding. Injection of the mu-opioid agonist DAMGO (at 0, 0.025, 0.25, or 2.5 µg/0.5 µl/side) directly into the rat… CONTINUE READING
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