CB1 receptor selective activation inhibits beta-amyloid-induced iNOS protein expression in C6 cells and subsequently blunts tau protein hyperphosphorylation in co-cultured neurons.

@article{Esposito2006CB1RS,
  title={CB1 receptor selective activation inhibits beta-amyloid-induced iNOS protein expression in C6 cells and subsequently blunts tau protein hyperphosphorylation in co-cultured neurons.},
  author={Giuseppe Esposito and Daniele De Filippis and Luca Steardo and Caterina Scuderi and Claudia Savani and Vincenzo Cuomo and Teresa Iuvone},
  journal={Neuroscience letters},
  year={2006},
  volume={404 3},
  pages={342-6}
}
Among the wide range of neuro-inflammatory signalling molecules released by beta-amyloid-stimulated astroglial cells, nitric oxide (NO) plays a fundamental role in AD aethiopathogenesis since it directly promotes neuronal tau protein hyperphosphorylation leading to neurofibrillary tangle formation. Synthetic cannabinoids (CBs), via a selective CB1 receptor activation, negatively modulates both iNOS protein expression and NO production induced by pro-inflammatory stimuli. In this study we… CONTINUE READING

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