CB1 receptor blockade decreases ethanol intake and associated neurochemical changes in fawn-hooded rats.

@article{Femena2010CB1RB,
  title={CB1 receptor blockade decreases ethanol intake and associated neurochemical changes in fawn-hooded rats.},
  author={Teresa Femen{\'i}a and Mar{\'i}a Salud Garc{\'i}a-Guti{\'e}rrez and Jorge Manzanares},
  journal={Alcoholism, clinical and experimental research},
  year={2010},
  volume={34 1},
  pages={131-41}
}
BACKGROUND This study was undertaken to identify the neurochemical changes underlying the attenuation of voluntary ethanol intake induced by the cannabinoid CB1 receptor antagonist AM251 in fawn-hooded rats. METHODS Rats were exposed to the 2-bottle-choice paradigm (ethanol 10% v/v or water) for 15 days. After this period, rats received AM251 (3 to 6 mg/kg, i.p.) or vehicle. RESULTS Voluntary ethanol intake decreased (30%) with the administration of incremental dosages of AM251 (3 mg/kg, 5… CONTINUE READING