CB1 cannabinoid receptors promote oxidative stress and cell death in murine models of doxorubicin-induced cardiomyopathy and in human cardiomyocytes.

@article{Mukhopadhyay2010CB1CR,
  title={CB1 cannabinoid receptors promote oxidative stress and cell death in murine models of doxorubicin-induced cardiomyopathy and in human cardiomyocytes.},
  author={Partha Mukhopadhyay and Mohanraj Rajesh and S{\'a}ndor B{\'a}tkai and Vivek A Patel and Yoshihiro Kashiwaya and Lucas Liaudet and Oleg V. Evgenov and Ken Mackie and Gy{\"o}rgy Hask{\'o} and P{\'a}l Pacher},
  journal={Cardiovascular research},
  year={2010},
  volume={85 4},
  pages={
          773-84
        }
}
AIMS Here we investigated the mechanisms by which cardiovascular CB1 cannabinoid receptors may modulate the cardiac dysfunction, oxidative stress, and interrelated cell death pathways associated with acute/chronic cardiomyopathy induced by the widely used anti-tumour compound doxorubicin (DOX). METHODS AND RESULTS Both load-dependent and -independent indices of left-ventricular function were measured by the Millar pressure-volume conductance system. Mitogen-activated protein kinase (MAPK… CONTINUE READING
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