CB1 cannabinoid receptors and on-demand defense against excitotoxicity.

@article{Marsicano2003CB1CR,
  title={CB1 cannabinoid receptors and on-demand defense against excitotoxicity.},
  author={Giovanni Marsicano and S. J. Goodenough and Krisztina Monory and Heike Hermann and Matthias Eder and Astrid Cannich and Shahnaz Christina Azad and Maria Grazia Cascio and Silvia Ortega Guti{\'e}rrez and Mario van der Stelt and Mar{\'i}a L. L{\'o}pez-Rodr{\'i}guez and Emilio Casanova and Guenther Schuetz and Walter Zieglg{\"a}nsberger and Vincenzo Di Marzo and Christian Behl and Beat Lutz},
  journal={Science},
  year={2003},
  volume={302 5642},
  pages={84-8}
}
Abnormally high spiking activity can damage neurons. Signaling systems to protect neurons from the consequences of abnormal discharge activity have been postulated. We generated conditional mutant mice that lack expression of the cannabinoid receptor type 1 in principal forebrain neurons but not in adjacent inhibitory interneurons. In mutant mice,the excitotoxin kainic acid (KA) induced excessive seizures in vivo. The threshold to KA-induced neuronal excitation in vitro was severely reduced in… CONTINUE READING
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