CB1 cannabinoid receptor-mediated modulation of food intake in mice.

  title={CB1 cannabinoid receptor-mediated modulation of food intake in mice.},
  author={Jenny L Wiley and J. J. Burston and Darnica C Leggett and Olga O Alekseeva and Raj K. Razdan and Anu Mahadevan and Billy R. Martin},
  journal={British journal of pharmacology},
  volume={145 3},
1 Marijuana's appetite-increasing effects have long been known. Recent research suggests that the CB(1) cannabinoid receptor antagonist SR141716A may suppress appetite. This study represents a further, systematic investigation of the role of CB(1) cannabinoid receptors in the pharmacological effects of cannabinoids on food intake. 2 Mice were food-restricted for 24 h and then allowed access to their regular rodent chow for 1 h. Whereas the CB(1) antagonist SR141716A dose-dependently decreased… CONTINUE READING
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