CB1 cannabinoid receptor knockout in mice leads to leanness, resistance to diet-induced obesity and enhanced leptin sensitivity

@article{Trillou2004CB1CR,
  title={CB1 cannabinoid receptor knockout in mice leads to leanness, resistance to diet-induced obesity and enhanced leptin sensitivity},
  author={C Ravinet Trillou and Claire Delgorge and Christel J Menet and Mich{\`e}le Arnone and Philippe Soubri{\'e}},
  journal={International Journal of Obesity},
  year={2004},
  volume={28},
  pages={640-648}
}
OBJECTIVE: There is growing evidence for an implication of the CB1 receptor subtype of the endocannabinoid system in the regulation of eating and fat deposition. To further define the physiological role of these receptors in the control of energy balance, we characterized the phenotype of CB1 receptor knockout (CB1−/−) mice maintained on an obesity-prone regimen or on a standard chow.DESIGN: CB1−/− male mice were compared to wild-type animals (CB1+/+ male mice) in two feeding paradigms: (1… CONTINUE READING
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