CB1 cannabinoid receptor‐mediated modulation of food intake in mice

  title={CB1 cannabinoid receptor‐mediated modulation of food intake in mice},
  author={J. Wiley and J. Burston and Darnica C Leggett and O. O. Alekseeva and R. Razdan and A. Mahadevan and B. Martin},
  journal={British Journal of Pharmacology},
  • J. Wiley, J. Burston, +4 authors B. Martin
  • Published 2005
  • Biology, Medicine
  • British Journal of Pharmacology
  • 1 Marijuana's appetite‐increasing effects have long been known. Recent research suggests that the CB1 cannabinoid receptor antagonist SR141716A may suppress appetite. This study represents a further, systematic investigation of the role of CB1 cannabinoid receptors in the pharmacological effects of cannabinoids on food intake. 2 Mice were food‐restricted for 24 h and then allowed access to their regular rodent chow for 1 h. Whereas the CB1 antagonist SR141716A dose‐dependently decreased food… CONTINUE READING
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