CB1 and CB2 cannabinoid receptors differentially regulate the production of reactive oxygen species by macrophages.

@article{Han2009CB1AC,
  title={CB1 and CB2 cannabinoid receptors differentially regulate the production of reactive oxygen species by macrophages.},
  author={Ki Hoon Han and Sunny Lim and Jewon Ryu and Cheol-Whan Lee and Yuna Kim and Ju-Hee Kang and Soon-Suk Kang and Yeong Ki Ahn and Chan-Sik Park and Jae Joong Kim},
  journal={Cardiovascular research},
  year={2009},
  volume={84 3},
  pages={
          378-86
        }
}
AIMS We investigated the mechanism by which cannabinoid receptors-1 (CB1) and -2 (CB2) modulate inflammatory activities of macrophages. METHODS AND RESULTS Real-time polymerase chain reaction showed the predominant CB2 expression in freshly isolated human monocytes. PMA, a potent inducer of differentiation, upregulated CB1 and increased CB1:CB2 transcript ratio from 1:17.5 to 1:3 in 5 days of culture. Immunohistochemistry showed that CB1 protein was colocalized in CD68- and CD36-positive… CONTINUE READING

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