CB1 and CB2 cannabinoid receptors are implicated in inflammatory pain

@article{Clayton2002CB1AC,
  title={CB1 and CB2 cannabinoid receptors are implicated in inflammatory pain},
  author={N. Clayton and F. Marshall and C. Bountra and C. T. O'shaughnessy},
  journal={Pain},
  year={2002},
  volume={96},
  pages={253-260}
}
  • N. Clayton, F. Marshall, +1 author C. T. O'shaughnessy
  • Published 2002
  • Medicine
  • Pain
  • &NA; The cannabinoid agonist, HU210 has been evaluated in vivo in nociceptive and inflammatory pain models in the rat. The ED50 for the anti‐nociceptive (increasing mechanical withdrawal threshold) effect was 0.1 mg/kg−1 i.p., and for anti‐hypersensitivity and anti‐inflammatory activity was 5 &mgr;g/kg−1 i.p. (in the carrageenan model). The selective CB1 antagonist, AM281 (0.5 mg/kg−1 i.p.) reversed effects of HU210 (10 and 30 &mgr;g/kg−1 i.p.) in both nociceptive and inflammatory models of… CONTINUE READING
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