CB₂ receptor deficiency increases amyloid pathology and alters tau processing in a transgenic mouse model of Alzheimer's disease.

@article{Koppel2013CBRD,
  title={CB₂ receptor deficiency increases amyloid pathology and alters tau processing in a transgenic mouse model of Alzheimer's disease.},
  author={Jeremy L Koppel and Val{\'e}rie Vingtdeux and Philippe Marambaud and Cristina d'Abramo and Heidy T. Jimenez and Mark Stauber and Rachel S. Friedman and Peter Howard Davies},
  journal={Molecular medicine},
  year={2013},
  volume={19},
  pages={
          357-64
        }
}
The endocannabinoid CB₂ receptor system has been implicated in the neuropathology of Alzheimer's disease (AD). In order to investigate the impact of the CB₂ receptor system on AD pathology, a colony of mice with a deleted CB₂ receptor gene, CNR2, was established on a transgenic human mutant APP background for pathological comparison with CB₂ receptor-sufficient transgenic mice. J20 APP (PDGFB-APPSwInd) mice were bred over two generations with CNR2⁻/⁻ (Cnr2(tm1Dgen)/J) mice to produce a colony… CONTINUE READING
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