CB₂ cannabinoid receptors inhibit synaptic transmission when expressed in cultured autaptic neurons.

@article{Atwood2012CBCR,
  title={CB₂ cannabinoid receptors inhibit synaptic transmission when expressed in cultured autaptic neurons.},
  author={Brady K. Atwood and Alex Straiker and Ken Mackie},
  journal={Neuropharmacology},
  year={2012},
  volume={63 4},
  pages={514-23}
}
The role of CB₂ in the central nervous system, particularly in neurons, has generated much controversy. Fueling the controversy are imperfect tools, which have made conclusive identification of CB₂ expressing neurons problematic. Imprecise localization of CB₂ has made it difficult to determine its function in neurons. Here we avoid the localization controversy and directly address the question if CB₂ can modulate neurotransmission. CB₂ was expressed in excitatory hippocampal autaptic neurons… CONTINUE READING