• Corpus ID: 54721809

CAT , GPX 1 , MnSOD , GSTM 1 , GSTT 1 , and GSTP 1 Genetic Polymorphisms in Chronic Myeloid Leukemia : A Case-Control Study

  title={CAT , GPX 1 , MnSOD , GSTM 1 , GSTT 1 , and GSTP 1 Genetic Polymorphisms in Chronic Myeloid Leukemia : A Case-Control Study},
  author={B. Claudia and Nescu and Adrian Pavel Trifa and Valeriu George Moldovan and IoanMacarie and Erzs{\'e}bet L{\'a}z{\'a}r and Delia Dima and Carmen Duicu and andMinodora Dobreanu},
1 Department of Medical Genetics, University of Medicine and Pharmacy Tirgu Mures, 38 Gh. Marinescu Street, 540139 Tirgu Mures, Romania 2Department of Medical Genetics, “Iuliu Hatieganu” University of Medicine and Pharmacy, 6 Louis Pasteur Street, 400349 Cluj-Napoca, Romania 3 Department of Epidemiology, University of Medicine and Pharmacy Tirgu Mures, 38 Gh. Marinescu Street, 540139 Tirgu Mures, Romania 4Hematology Clinic 1, University of Medicine and Pharmacy Tirgu Mures, 50 Gh. Marinescu… 
6 Citations

Tables from this paper

From Six Gene Polymorphisms of the Antioxidant System, Only GPX Pro198Leu and GSTP1 Ile105Val Modulate the Risk of Acute Myeloid Leukemia

The data suggests that the presence of variant allele and genotype of GPX1 Pro198Leu and GSTP1 Ile105Val gene polymorphisms may modulate the risk of developing acute myeloid leukemia.

Association of GPx1 P198L and CAT C-262T Genetic Variations With Polycystic Ovary Syndrome in Chinese Women

The subjects with both GPx1 L and SOD2 A alleles further increase the risk of PCOS compared with the individuals carrying the PP/VV genotype after adjusting for age and BMI, and no significant differences were observed in the frequencies of the CAT C-262T genotypes and alleles between PCOS and control groups.

Age- and gender-independent association of glutathione S-transferase null polymorphisms with chronic myeloid leukemia.

The GSTT1 and GSTM1 null polymorphisms are associated with CML among Sudanese patients, independently of their age and gender.

GSTP1 and cancer: Expression, methylation, polymorphisms and signaling (Review).

The aim of the present study was to review the association between the expression of GSTP1 and the development and treatment of various cancers, and discuss GSTP 1 methylation in several malignant tumors.

The Role of Catalase C262T Gene Polymorphism in the Susceptibility and Survival of Cancers

The CAT C262T polymorphism may be a candidate marker for cancer risk with type-specific and population-specific effects but not a fine prognostic factor for cancer survival.



Comparative analysis of GSTM1/GSTT1 null alleles and Ile105Val GSTP1 variant in patients with Nasal Polyposis and hyposmia in a Romanian population group

The presence of both GSTM1/GSTT1 null genotypes (doublenull genotypes) is considered to be a risk factor for NP and hyposmia development in allergic individuals and the results of the study show no correlation between Ile105Val polymorphism of GSTP1 gene and nasal polyposis associated hyposia in this Romanian group population.

Frequency of polymorphisms pro198leu in GPX-1 gene and ile58thr in MnSOD gene in the altitude Ecuadorian population with bladder cancer.

The results indicate that polymorphism of GPX-1 gene influences the risk of developing bladder cancer in the Ecuadorian population, suggesting that more research on detoxifying genes in bladder cancer should be conducted.

Genetic polymorphisms of GSTM1 and GSTT1 genes in Delhi and comparison with other Indian and global populations.

The results are reliable estimates of the frequencies of the GSTM1, GSTT1 in Delhi and would provide a basic database for future clinical and genetic studies pertaining to susceptibility and inconsistency in the response and/or toxicity to drugs known to be the substrates for GSTs.

CYP1A1, GST gene polymorphisms and risk of chronic myeloid leukemia.

Data suggests that polymorphic CYP1A1 and GSTT1 genes appear to affect susceptibility to chronic myeloid leukaemia.

Variations in glutathione‐S‐transferase genes influence risk of chronic myeloid leukemia

An association between the GSTT1‐ genotype, either alone or in combination with GSTM1‐genotype, and risk of CML is indicated, suggesting a possible interaction between GSTM2 and GSTT2 and further research is warranted.

Polymorphic variation in glutathione-S-transferase genes and risk of chronic myeloid leukaemia in the Kashmiri population.

The presence of GSTT1 genotype may have protective role against the CML, and individuals carrying null genotypes of both GSTM1 and GSTT2 genes are at elevated risk of CML.

Glutathione S-transferase gene polymorphisms and susceptibility to chronic myeloid leukemia

It is suggested that heritable GST status influences the risk of developing CML and that more attention should be paid to carriers of these susceptibility genes.

Association of the GSTP1 gene (Ile105Val) polymorphism with chronic myeloid leukemia.

It is suggested that GSTP 1 Ile105Val polymorphism with reduced GSTP1 enzyme activity might influence CML development, progression and response rates.

CAT C-262T and GPX1 Pro198Leu polymorphisms in a Turkish population

The aim of this study was to assess the distribution of CAT C-262T and GPX1 Pro198Leu genotypic variants in a Turkish population and showed marked ethnic group differences.

Investigation of GSTP1 (Ile105Val) Gene Polymorphism in Chronic Myeloid Leukaemia Patients

The results provide no evidence of a relationship between the GSTP1 (IIe105Val) gene polymorphism and susceptibility to CML in Turkish patients, and these findings should be confirmed in studies with larger sample sizes.