CAT, GPX1, MnSOD, GSTM1, GSTT1, and GSTP1 Genetic Polymorphisms in Chronic Myeloid Leukemia: A Case-Control Study

@article{Bnescu2014CATGM,
  title={CAT, GPX1, MnSOD, GSTM1, GSTT1, and GSTP1 Genetic Polymorphisms in Chronic Myeloid Leukemia: A Case-Control Study},
  author={Claudia Bănescu and Adrian Pavel Trifa and Septimiu Voidăzan and Valeriu George Moldovan and Ioan Macarie and Erzs{\'e}bet Benedek L{\'a}z{\'a}r and Delia Dima and Carmen Duicu and Minodora Dobreanu},
  journal={Oxidative Medicine and Cellular Longevity},
  year={2014},
  volume={2014}
}
Oxidative damage at the DNA level may be promoted by high levels of reactive oxygen species (ROS), leading to genomic instability and increased neoplastic risk. Superoxide dismutase (SOD), glutathione peroxidase (GPX), and catalase (CAT) enzymes are implicated in the prevention of DNA damage by ROS. The aim of the study was to investigate the relationships between CAT C262T, GPX1 Pro198Leu, MnSOD Ala16Val, GSTM1, GSTT1, and GSTP1 Ile105Val polymorphisms and the risk of CML. No association was… 

Tables from this paper

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References

SHOWING 1-10 OF 25 REFERENCES
Risk effects of GST gene polymorphisms in patients with acute myeloid leukemia: a prospective study.
TLDR
Findings indicate that genetic variants of GST and especially the GSTT1 gene have a critical function in the development of AML, and offers important insights into the molecular etiology ofAML.
Association of the GSTP1 gene (Ile105Val) polymorphism with chronic myeloid leukemia.
TLDR
It is suggested that GSTP 1 Ile105Val polymorphism with reduced GSTP1 enzyme activity might influence CML development, progression and response rates.
CAT C-262T and GPX1 Pro198Leu polymorphisms in a Turkish population
TLDR
The aim of this study was to assess the distribution of CAT C-262T and GPX1 Pro198Leu genotypic variants in a Turkish population and showed marked ethnic group differences.
Comparative analysis of GSTM1/GSTT1 null alleles and Ile105Val GSTP1 variant in patients with Nasal Polyposis and hyposmia in a Romanian population group
TLDR
The presence of both GSTM1/GSTT1 null genotypes (doublenull genotypes) is considered to be a risk factor for NP and hyposmia development in allergic individuals and the results of the study show no correlation between Ile105Val polymorphism of GSTP1 gene and nasal polyposis associated hyposia in this Romanian group population.
Variations in glutathione‐S‐transferase genes influence risk of chronic myeloid leukemia
TLDR
An association between the GSTT1‐ genotype, either alone or in combination with GSTM1‐genotype, and risk of CML is indicated, suggesting a possible interaction between GSTM2 and GSTT2 and further research is warranted.
Genetic polymorphisms of GSTM1 and GSTT1 genes in Delhi and comparison with other Indian and global populations.
TLDR
The results are reliable estimates of the frequencies of the GSTM1, GSTT1 in Delhi and would provide a basic database for future clinical and genetic studies pertaining to susceptibility and inconsistency in the response and/or toxicity to drugs known to be the substrates for GSTs.
Polymorphic variation in glutathione-S-transferase genes and risk of chronic myeloid leukaemia in the Kashmiri population.
TLDR
The presence of GSTT1 genotype may have protective role against the CML, and individuals carrying null genotypes of both GSTM1 and GSTT2 genes are at elevated risk of CML.
Glutathione S-transferase P1 Genotype and Prognosis in Hodgkin's Lymphoma
TLDR
The GSTP1 genotype predicts clinical outcome in patients with Hodgkin's lymphoma and was an independent prognostic factor in the Cox multivariate analysis.
Genetic polymorphisms of superoxide dismutases, catalase, and glutathione peroxidase in age-related cataract
TLDR
The G/G genotype of the SOD1–251A/G polymorphism may be associated with an increased risk of cataract, however, in CAT–21A/T and GPX1–198C/T polymorphisms, there were no significant differences in the variant homozygous frequencies in patients compared to controls.
Glutathione peroxidase codon 198 polymorphism variant increases lung cancer risk.
TLDR
A case-control study nested within the alpha-Tocopherol, beta-Carotene Cancer Prevention Study cohort to evaluate the association between the proline to leucine polymorphism at codon 198 of h GPX1 and lung cancer risk found a significant association between hGPX1 genotype and lungcancer risk.
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