CAT, GPX1, MnSOD, GSTM1, GSTT1, and GSTP1 Genetic Polymorphisms in Chronic Myeloid Leukemia: A Case-Control Study

@article{Bnescu2014CATGM,
  title={CAT, GPX1, MnSOD, GSTM1, GSTT1, and GSTP1 Genetic Polymorphisms in Chronic Myeloid Leukemia: A Case-Control Study},
  author={Claudia Bănescu and Adrian Pavel Trifa and Septimiu Voidăzan and Valeriu George Moldovan and Ioan Macarie and Erzs{\'e}bet Benedek L{\'a}z{\'a}r and Delia Dima and Carmen Duicu and Minodora Dobreanu},
  journal={Oxidative Medicine and Cellular Longevity},
  year={2014},
  volume={2014}
}
Oxidative damage at the DNA level may be promoted by high levels of reactive oxygen species (ROS), leading to genomic instability and increased neoplastic risk. Superoxide dismutase (SOD), glutathione peroxidase (GPX), and catalase (CAT) enzymes are implicated in the prevention of DNA damage by ROS. The aim of the study was to investigate the relationships between CAT C262T, GPX1 Pro198Leu, MnSOD Ala16Val, GSTM1, GSTT1, and GSTP1 Ile105Val polymorphisms and the risk of CML. No association was… 
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From Six Gene Polymorphisms of the Antioxidant System, Only GPX Pro198Leu and GSTP1 Ile105Val Modulate the Risk of Acute Myeloid Leukemia
TLDR
The data suggests that the presence of variant allele and genotype of GPX1 Pro198Leu and GSTP1 Ile105Val gene polymorphisms may modulate the risk of developing acute myeloid leukemia.
Genetic Polymorphism of GSTP1, GSTM1 and GSTT1 Genes and Susceptibility to Chronic Myeloid Leukaemia
TLDR
The presence of the GSTT1 genotype may be a protective factor for CML, while the null genotype shows association with developing CML.
GSTM1 and GSTP1, but not GSTT1 genetic polymorphisms are associated with chronic myeloid leukemia risk and treatment response.
Combined GSTT1 Null, GSTM1 Null and XPD Lys/Lys Genetic Polymorphisms and Their Association with Increased Risk of Chronic Myeloid Leukemia
TLDR
Investigating GSTT1, GSTM1 and XPD polymorphisms in newly diagnosed chronic myeloid leukemia patients showed positive association with the risk of development of CML, while CML phases were associated with GSTT 1 null polymorphism.
Frequency Of GSTP1 (Ile105Val) Gene Polymorphism In Iraqi CML Patients And Its Association With Susceptibility To CML
TLDR
Evaluating the frequency of Glutathione S transferase P1 (Ile105Val) gene polymorphism in Iraqi chronic myeloid leukaemia patients and its association with susceptibility to CML revealed more than threefold higher CML risk among subjects exhibiting the variant genotype, indicating that (I-105-Val) polymorphic variants of GSTP1 gene might confer a higher risk of CML development.
Among a panel of polymorphisms in genes related to oxidative stress, CAT-262 C>T, GPX1 Pro198Leu and GSTP1 Ile105Val influence the risk of developing BCR-ABL negative myeloproliferative neoplasms
TLDR
Evidence is provided that variation in genes related to oxidative stress might modulate the risk of developing BCR-ABL negative myeloproliferative neoplasms.
The Influence of GPX1 Pro198Leu, CAT C262T and MnSOD Ala16Val Gene Polymorphisms on Susceptibility for Non-Hodgkin Lymphoma and Overall Survival Rate at Five Years from Diagnosis
TLDR
The mentioned polymorphisms may be considered as susceptible markers of the five-year overall survival rate for NHL patients and future studies with a larger number of patients are needed to confirm the results.
Status of Catalase, Glutathione Peroxidase, Glutathione S-Transferase, and Myeloperoxidase Gene Polymorphisms in Beta-Thalassemia Major Patients to Assess Oxidative Injury and Its Association with Enzyme Activities
TLDR
The results suggest that frequency of null allele of glutathione-S-transferase is significantly high among thalassemia major patients, and the other alleles CT-89 (A > T), GPx1 198 (C‬>‬T), and MPO-463 (G‬‬A) are linked to decreased CT, GPX, andMPO enzyme activities.
Association between Polymorphisms of Antioxidant Gene (MnSOD, CAT, and GPx1) and Risk of Coronary Artery Disease
TLDR
MnSOD polymorphism is an independent risk factor for susceptibility to CAD in the Chinese population and the interaction between MnSOD genotype and cigarette smoking was not significant.
Association of GPx1 P198L and CAT C-262T Genetic Variations With Polycystic Ovary Syndrome in Chinese Women
TLDR
The subjects with both GPx1 L and SOD2 A alleles further increase the risk of PCOS compared with the individuals carrying the PP/VV genotype after adjusting for age and BMI, and no significant differences were observed in the frequencies of the CAT C-262T genotypes and alleles between PCOS and control groups.
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