CASK is in the mammalian sperm head and is processed during epididymal maturation.

@article{Burkin2004CASKII,
  title={CASK is in the mammalian sperm head and is processed during epididymal maturation.},
  author={Heather R Burkin and Longmei Zhao and David J Miller},
  journal={Molecular reproduction and development},
  year={2004},
  volume={68 4},
  pages={
          500-6
        }
}
Upon adhesion to the zona pellucida or egg extracellular matrix, sperm undergo regulated exocytosis of the acrosomal vesicle. CASK is an adaptor protein that has been implicated in coupling neuronal cell adhesion to regulated exocytosis. In neurons, this scaffolding molecule is associated with several types of transmembrane receptor complexes and connects cell adhesion molecules with ion channels, the actin cytoskeleton, and the cell's exocytotic machinery. We hypothesized CASK might also be an… CONTINUE READING

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