CASK and its target gene Reelin were co-upregulated in human esophageal carcinoma.

Abstract

Calcium/calmodulin-dependent serine protein kinase (CASK) showed overexpression in human esophageal carcinoma by suppression subtractive hybridization. The upregulation of CASK gene and its target gene Reelin in human esophageal carcinoma tissues versus corresponding normal tissues was revealed by reverse transcription polymerase chain reaction (RT-PCR), immunohistochemistry or Western blot. Moreover, RT-PCR results indicated that the expression patterns of CASK and Reelin in human gastric carcinoma and colon carcinoma were different with those in esophageal carcinoma. Therefore, it suggested that CASK and Reelin were associated with tumorigenesis of esophagus and they were co-upregulated in human esophageal carcinoma.

Cite this paper

@article{Wang2002CASKAI, title={CASK and its target gene Reelin were co-upregulated in human esophageal carcinoma.}, author={Qun Wang and Jiayun Lu and Cuihong Yang and Xiuqin Wang and Lu Cheng and Gengxi Hu and Yuntian Sun and Xun Zhang and Min Wu and Zhihua Liu}, journal={Cancer letters}, year={2002}, volume={179 1}, pages={71-7} }