CASH, a novel caspase homologue with death effector domains.

  title={CASH, a novel caspase homologue with death effector domains.},
  author={Yuri Goltsev and Andrew V Kovalenko and Eddy Arnold and Eugene Varfolomeev and V M Brodianskiĭ and David Wallach},
  journal={The Journal of biological chemistry},
  volume={272 32},
CASP-8 and CASP-10, members of a cysteine protease family that participates in apoptosis, interact with MORT1/FADD, an adapter protein in the CD120a (p55 tumor necrosis factor receptor), and CD95 (Fas/Apo-1) death-inducing signaling pathways, through a shared N-terminal sequence motif, the death effector domain. We report cloning of two splice variants of a novel protein, CASH, that contain two N-terminal death effector domains and can bind through them to each other, to MORT1/FADD, to CASP-8… CONTINUE READING
106 Citations
0 References
Similar Papers


Publications citing this paper.
Showing 1-10 of 106 extracted citations

Similar Papers

Loading similar papers…