CAS proteins in health and disease: an update.

  title={CAS proteins in health and disease: an update.},
  author={Anna S. Nikonova and Anna V. Gaponova and Alexander E Kudinov and Erica A Golemis},
  journal={IUBMB life},
  volume={66 6},
The CAS family of scaffolding proteins has increasingly attracted scrutiny as important for regulation of cancer-associated signaling. BCAR1 (also known as p130Cas), NEDD9 (HEF1, Cas-L), EFS (Sin), and CASS4 (HEPL) are regulated by and mediate cell attachment, growth factor, and chemokine signaling. Altered expression and activity of CAS proteins are now… CONTINUE READING