CART regulates islet hormone secretion and is expressed in the beta-cells of type 2 diabetic rats.

@article{Wierup2006CARTRI,
  title={CART regulates islet hormone secretion and is expressed in the beta-cells of type 2 diabetic rats.},
  author={Nils Wierup and Maria Bj{\"o}rkqvist and Michael Kuhar and Hindrik Mulder and Frank Sundler},
  journal={Diabetes},
  year={2006},
  volume={55 2},
  pages={305-11}
}
Cocaine- and amphetamine-regulated transcript (CART) is an anorexigenic peptide widely expressed in the central, peripheral, and enteric nervous systems. CART is also expressed in endocrine cells, including beta-cells during rat development and delta-cells of adult rats. We examined the effect of CART 55-102 on islet hormone secretion, using INS-1(832/13) cells and isolated rat islets. In addition, islet CART expression was examined in two rat models of type 2 diabetes: Goto-Kakizaki (GK) rats… CONTINUE READING