CART regulates islet hormone secretion and is expressed in the beta-cells of type 2 diabetic rats.

@article{Wierup2006CARTRI,
  title={CART regulates islet hormone secretion and is expressed in the beta-cells of type 2 diabetic rats.},
  author={N. Wierup and M. Bj{\"o}rkqvist and M. Kuhar and H. Mulder and F. Sundler},
  journal={Diabetes},
  year={2006},
  volume={55 2},
  pages={
          305-11
        }
}
  • N. Wierup, M. Björkqvist, +2 authors F. Sundler
  • Published 2006
  • Biology, Medicine
  • Diabetes
  • Cocaine- and amphetamine-regulated transcript (CART) is an anorexigenic peptide widely expressed in the central, peripheral, and enteric nervous systems. CART is also expressed in endocrine cells, including beta-cells during rat development and delta-cells of adult rats. We examined the effect of CART 55-102 on islet hormone secretion, using INS-1(832/13) cells and isolated rat islets. In addition, islet CART expression was examined in two rat models of type 2 diabetes: Goto-Kakizaki (GK) rats… CONTINUE READING
    Glucose enhances rat islet function via stimulating CART expression.
    2
    CART is a novel islet regulatory peptide
    45
    CART is overexpressed in human type 2 diabetic islets and inhibits glucagon secretion and increases insulin secretion
    12
    The role of CART in islet function
    The role of cocaine- and amphetamine-regulated transcript in endocrine cells

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