CARMIL is a potent capping protein antagonist: identification of a conserved CARMIL domain that inhibits the activity of capping protein and uncaps capped actin filaments.

@article{Uruno2006CARMILIA,
  title={CARMIL is a potent capping protein antagonist: identification of a conserved CARMIL domain that inhibits the activity of capping protein and uncaps capped actin filaments.},
  author={Takehito Uruno and Kirsten Remmert and John A Hammer},
  journal={The Journal of biological chemistry},
  year={2006},
  volume={281 15},
  pages={10635-50}
}
Acanthamoeba CARMIL was previously shown to co-purify with capping protein (CP) and to bind pure CP. Here we show that this interaction inhibits the barbed end-capping activity of CP. Even more strikingly, this interaction drives the uncapping of actin filaments previously capped with CP. These activities are CP-specific; CARMIL does not inhibit the capping… CONTINUE READING