Corpus ID: 25340502

CARMA 3 is Crucial for EGFR-Induced Activation of NFk B and Tumor Progression

  title={CARMA 3 is Crucial for EGFR-Induced Activation of NFk B and Tumor Progression},
  author={Tang Jiang and Brian C. Grabiner and Yifan Zhu and Changying Jiang and Hongxiu Li and Yun You and Jingyu Lang and Mien-Chie Hung and Xin Lin},
EGF activates NF-kB, and constitutively activated NF-kB contributes to EGFR mutation-associated tumorigenesis, but it remains unclear precisely how EGFR signaling leads to NF-kB activation. Here we report that CARMA3, a caspase recruitment domain (CARD)-containing scaffold molecule, is required for EGF-induced NFkB activation. CARMA3 deficiency impaired the activation of the IKK complex following EGF stimulation, resulting in a defect of EGF-induced IkBa phosphorylation and NF-kB activation. We… Expand
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