CARMA 3 Bcl 10 MALT 1-dependent NF-B activation mediates angiotensin II-responsive inflammatory signaling in nonimmune cells

@inproceedings{McAllisterLucas2006CARMA3B,
  title={CARMA 3 Bcl 10 MALT 1-dependent NF-B activation mediates angiotensin II-responsive inflammatory signaling in nonimmune cells},
  author={Linda M. McAllister-Lucas and Juergen Ruland and Katy Pak-Yan Siu and Xiaohong Jin and Shufang Gu and David S. L. Kim and Peter Kuffa and Dawn Kohrt and Tak W Mak and Gabriel N{\'u}{\~n}ez and Peter C. Lucas},
  year={2006}
}
Angiotensin II (Ang II) is a peptide hormone that, like many cytokines, acts as a proinflammatory agent and growth factor. After injury to the liver, the hormone assists in tissue repair by stimulating hepatocytes and hepatic stellate cells to synthesize extracellular matrix proteins and secrete secondary cytokines and by stimulating myofibroblasts to proliferate. However, under conditions of chronic liver injury, all of these effects conspire to promote pathologic liver fibrosis. Much of this… CONTINUE READING