CARF is a novel protein that cooperates with mouse p19ARF (human p14ARF) in activating p53.

Abstract

The INK4a locus on chromosome 9p21 encodes two structurally distinct tumor suppressor proteins, p16(INK4a) and the alternative reading frame protein, ARF (p19(ARF) in mouse and p14(ARF) in human). Each of these proteins has a role in senescence of primary cells and activates pathways for cell cycle control and tumor suppression. The current prevailing model… (More)

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Cite this paper

@article{Hasan2002CARFIA, title={CARF is a novel protein that cooperates with mouse p19ARF (human p14ARF) in activating p53.}, author={Md Kamrul Hasan and Tomoko Yaguchi and Takashi Sugihara and Penmetcha K R Kumar and Kazunari Taira and Roger R Reddel and Sunil C. Kaul and Renu Wadhwa}, journal={The Journal of biological chemistry}, year={2002}, volume={277 40}, pages={37765-70} }