CARDIOPULMONARY AND ANESTHETIC EFFECTS OF MEDETOMIDINE–KETAMINE–BUTORPHANOL AND ANTAGONISM WITH ATIPAMEZOLE IN SERVALS (FELIS SERVAL)

@inproceedings{Langan2000CARDIOPULMONARYAA,
  title={CARDIOPULMONARY AND ANESTHETIC EFFECTS OF MEDETOMIDINE–KETAMINE–BUTORPHANOL AND ANTAGONISM WITH ATIPAMEZOLE IN SERVALS (FELIS SERVAL)},
  author={Jennifer Langan and Juergen P Schumacher and Christal G. Pollock and Susan E. Orosz and M. P. Jones and Ralph C. Harvey},
  booktitle={Journal of zoo and wildlife medicine : official publication of the American Association of Zoo Veterinarians},
  year={2000}
}
Abstract Seven (three male and four female) 4–7-yr old captive servals (Felis serval) weighing 13.7 ± 2.3 kg were used to evaluate the cardiopulmonary and anesthetic effects of combined intramuscular injections of medetomidine (47.4 ± 10.3 µg/kg), ketamine (1.0 ± 0.2 mg/kg), and butorphanol (0.2 ± 0.03 mg/kg). Inductions were smooth and rapid (11.7 ± 4.3 min) and resulted in good muscle relaxation. Significant decreases in heart rate (85 ± 12 beats/min) at 10 min after injection and respiratory… 

Evaluation of Medetomidine–Ketamine–Butorphanol Anesthesia with Atipamezole–Naltrexone Antagonism in Captive Male Guanacos (Lama guanicoe)

TLDR
Average heart rates decreased during the procedures, but median heart rate, temperature, respiratory rate, and end-tidal carbon dioxide values over the 20 min monitoring period were not significantly different.

EVALUATION OF TWO DOSES OF BUTORPHANOL-MEDETOMIDINE-MIDAZOLAM FOR THE IMMOBILIZATION OF WILD VERSUS CAPTIVE BLACK-FOOTED CATS (FELIS NIGRIPES)

TLDR
BMM is a safe, effective immobilizing drug combination for both captive and wild black-footed cats, but higher doses are required in wild animals, especially in pursued animals due to hypoxia.

MEDETOMIDINE–KETAMINE–BUTORPHANOL ANESTHETIC COMBINATIONS IN BINTURONGS (ARCTICTIS BINTURONG)

  • A. MorescoR. Larsen
  • Biology, Medicine
    Journal of zoo and wildlife medicine : official publication of the American Association of Zoo Veterinarians
  • 2003
TLDR
The efficacy, safety, and reliability of two ketamine–medetomidine–butorphanol anesthetic combinations were evaluated in 34 adult binturongs and the LK combination is preferable because the mean recovery time was shorter.

Evaluation of the Effects of Naloxone on Recovery Time and Quality after Ketamine-Medetomidine-Butorphanol Anesthesia in Servals (Leptailurus serval)

TLDR
It is suggested that butorphanol does not routinely need to be antagonized in captive servals that are anesthetized with these dosages of ketamine, medetomidine, andbutorphanol, and it may be more important to administer opioid antagonists in free-ranging animals, where residual sedation would be more detrimental.

Use of Medetomidine for Sedation in the Laboratory Rat ( Rattus norvegicus )

TLDR
The recommendation regarding rat sedation is to apply medetomidine from 150 to 250 µg/kg, as higher dosages induce a relatively strong respiratory depression.

Electrocardiographic and Blood Pressure Measurements in Captive African Lions (Panthera leo) Immobilized with Xylazine-Ketamine Combination.

  • T. OmobowaleP. Otuh A. Adeogun
  • Biology, Medicine
    Nigerian journal of physiological sciences : official publication of the Physiological Society of Nigeria
  • 2017
TLDR
A strong positive correlation was found between hindlimb and tail comparisons of those parameters of SBP, DBP and MAP and should serve as a guide in the cardiovascular monitoring of captive African Lions immobilized with axylazine-ketamine combination.

Electrocardiographic Parameters of Captive Lions (Panthera leo) and Tigers (Panthera tigris) Immobilized with Ketamine Plus Xylazine

  • M. LarssonF. Coelho F. H. Ito
  • Medicine
    Journal of zoo and wildlife medicine : official publication of the American Association of Zoo Veterinarians
  • 2008
TLDR
Wider investigations on the same subject are necessary to establish criteria for the recognition of abnormalities in these species and should include other anesthetic drug(s) combinations and reports of electrocardiographic features of animals with cardiac disease and electrolytes disturbances.

Does mean arterial blood pressure scale with body mass in mammals? Effects of measurement of blood pressure

TLDR
The existing literature does not provide evidence for either a positive or neutral scaling of arterial pressure to body mass across taxa.

Efeitos cardiovasculares da medetomidina e cetamina em Puma concolor e tempo de recuperação após aplicação de ioimbina ou atipamezole

TLDR
A associação anestésica promoveu anestesia eficiente, segura e de rápida indução em onças-pardas, permitindo a imobilização dos animais durante os 90 minutos of avaliação, sem a ocorrência of complicações.

References

SHOWING 1-10 OF 28 REFERENCES

A comparative study of medetomidine-butorphanol-ketamine and medetomidine-ketamine anaesthesia in dogs.

TLDR
MBK anaesthesia is effective and widely available for therapeutic procedures depending upon the selection of the ketamine dose and the analgesic effects of MBK were more potent than those of MK.

Comparison of sedative and cardiorespiratory effects of medetomidine and medetomidine-butorphanol combination in dogs.

TLDR
Sedative, cardiorespiratory, and analgesic effects of intramuscular administration of medetomidine and butorphanol were compared and it was found that these drug combinations were effective combination for mildly invasive procedures.

Medetomidine as a preanesthetic prior to ketamine-HCL and halothane anesthesia in laboratory beagles.

TLDR
The potent sedative and analgesic effects of medetomidine confirm its potential use as a premedication to general anesthesia in dogs, and the positive chronotropic and inotropic properties of ketamine restored the medetamidine induced bradycardia and produced a short anesthetic period of 15-30 min depending on the dose.

Medetomidine Ketamine Anesthesia in Cats

TLDR
It was concluded that the medetomidine/ketamine combination provided a suitable anaesthesia for cats characterized by rapid induction, good muscle relaxation, good analgesia and bradycardia.

The clinical efficacy of medetomidine.

  • T. Vähä-Vahe
  • Medicine, Biology
    Acta veterinaria Scandinavica. Supplementum
  • 1989
TLDR
Medetomidine appears to be a potent sedative and analgesic agent for clinical use and has been shown to be useful for anesthesia and immobilization in cats and zoo animals.

Chemical restraint of African lions (Panthera leo) with medetomidine-ketamine.

TLDR
Atipamezole, at four times the preceding dose of medetomidine, provided a smooth recovery and animals were able to stand up 17-61 min after its injection, and side effects were limited to vomiting after walking in 3 of 5 lions.

Comparison of the clinical utility of medetomidine/ketamine and xylazine/ketamine combinations for the ovariectomy of cats

TLDR
The advantages of the medetomidine/ketamines combination in comparison with xylazine/ketamine were the need for a lower dose of ketamine, a longer duration of action and better analgesia, and similar side effects were observed.

Cardiopulmonary effects of xylazine in dogs.

TLDR
Heart rate and aortic flow decreased significantly, but statistically significant changes did not occur in aorti blood pressure or peripheral resistance; however, the changes in these last 2 values were in the same direction and were of similar magnitude as those which occurred afger IV administration of xylazine.

Cardiopulmonary effects of xylazine in dogs.

TLDR
Heart rate and aortic flow decreased significantly, but statistically significant changes did not occur in aorti blood pressure or peripheral resistance; however, the changes in these last 2 values were in the same direction and were of similar magnitude as those which occurred afger IV administration of xylazine.

Immobilization of Norwegian Reindeer (Rangifer tarandus tarandus) and Svalbard Reindeer (R. t. platyrhynchus) with Medetomidine and Medetomidine-Ketamine and Reversal of Immobilization with Atipamezole

TLDR
Atipamezole successfully antagonized medetomidine (-ketamine) resulting in rapid and persistent reversal of immobilization in all cases (NR and SR), which had wide safety margins and no conspicuous lasting side effects after reversal.