CARDIOPROTECTIVE EFFECTS OF A NON‐ALCOHOLIC EXTRACT OF RED WINE DURING ISCHAEMIA AND REPERFUSION IN SPONTANEOUSLY HYPERTENSIVE RATS

@article{Fantinelli2007CARDIOPROTECTIVEEO,
  title={CARDIOPROTECTIVE EFFECTS OF A NON‐ALCOHOLIC EXTRACT OF RED WINE DURING ISCHAEMIA AND REPERFUSION IN SPONTANEOUSLY HYPERTENSIVE RATS},
  author={Juliana C. Fantinelli and Susana M Mosca},
  journal={Clinical and Experimental Pharmacology and Physiology},
  year={2007},
  volume={34}
}
1 We reported recently the cardioprotection conferred by a non‐alcoholic extract of Cabernet‐Sauvignon red wine (RWE) against alterations derived from ischaemia and reperfusion in normotensive rats. The aim of the present study was to assess the effects of RWE on ischaemia/reperfusion injury in hearts isolated from spontaneously hypertensive rats (SHR). 2 After stabilization, rat isovolumic perfused hearts were exposed to a 20 min global ischaemic period followed by 30 min reperfusion in the… 
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References

SHOWING 1-10 OF 18 REFERENCES
Cardioprotection From Ischemia/Reperfusion Induced by Red Wine Extract Is Mediated by KATP Channels
TLDR
It is shown for the first demonstration that mitochondrial KATP channels and nitric oxide are involved in the protection against ischemia/reperfusion conferred by a nonalcoholic RWE.
Antihypertensive, vasodilator and antioxidant effects of a vinifera grape skin extract
TLDR
The findings suggest that the beneficial effect of moderate red wine consumption could be owing to an antihypertensive action induced by compounds occurring in the skin of vinifera grapes.
Red wine polyphenols prevent cardiovascular alterations in L-NAME-induced hypertension
TLDR
Evidence is provided that Provinols partially prevents L-NAME-induced hypertension, cardiovascular remodeling and vascular dysfunction via the increase of NO-synthase activity and prevention of oxidative stress.
Mechanism of the Endothelium-Dependent Vasodilation and the Antihypertensive Effect of Brazilian Red wine
TLDR
The present results demonstrated that vasodilator effect of BRW is dependent on endothelium-derived hyperpolarizing factor (EDHF) in combination with nitric oxide (NO), which may play a significant role on the cardioprotective action of chronic red wine consumption.
Effect of Antioxidant Therapy on Blood Pressure and NO Synthase Expression in Hypertensive Rats
TLDR
The role of oxidative stress in the genesis and/or maintenance of hypertension and compensatory upregulation of the expression of eNOS and iNOS in SHR is supported.
Antidiabetic activity of red wine polyphenolic extract, ethanol, or both in streptozotocin-treated rats.
TLDR
A polyphenol extract from red wine ("used at a pharmacological" dose) reduces glycemia and decreases food intake and body growth in diabetic and nondiabetic animals and ethanol administered alone or in combination with polyphenols is able to correct the diabetic state.
Polyphenols and red wine as antioxidants against peroxynitrite and other oxidants.
TLDR
It is concluded that the use of sensitive biological systems (as the aortic ring chemiluminescence) provides important information in addition to the results from chemical (NADH oxidation by peroxynitrite) and biochemical (homogenate chemilumscence) assays and offers advances in the physiological role of polyphenols.
Red wine polyphenols alone or in association with ethanol prevent hypertension, cardiac hypertrophy, and production of reactive oxygen species in the insulin-resistant fructose-fed rat.
TLDR
It is shown that polyphenols are able to prevent cardiac hypertrophy and production of reactive oxygen species in the insulin resistant fructose-fed rat.
Molecular and cellular mechanisms of myocardial stunning.
TLDR
An important implication of the phenomenon of myocardial stunning is that so-called chronic hibernation may in fact be the result of repetitive episodes of stunning, which have a cumulative effect and cause protracted postischemic dysfunction.
Wine Drinking and Risks of Cardiovascular Complications After Recent Acute Myocardial Infarction
TLDR
Whereas moderate wine drinking was associated with a significant reduction in the risk of complications in this homogenous population of coronary heart disease patients, further studies are required to confirm the data, define the clinical and biological profile of the patients who would most benefit from wine drinking after recent AMI, and examine whether the relations found are due to ethanol or other wine ingredients.
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