CARDINAL, a novel caspase recruitment domain protein, is an inhibitor of multiple NF-kappa B activation pathways.

@article{BouchierHayes2001CARDINALAN,
  title={CARDINAL, a novel caspase recruitment domain protein, is an inhibitor of multiple NF-kappa B activation pathways.},
  author={Lisa Bouchier-Hayes and Helen Conroy and Harnett Egan and Colin Adrain and Emma M. Creagh and Marion Macfarlane and Seamus J. Martin},
  journal={The Journal of biological chemistry},
  year={2001},
  volume={276 47},
  pages={44069-77}
}
Proteins possessing the caspase recruitment domain (CARD) motif have been implicated in pathways leading to activation of caspases or NF-kappaB in the context of apoptosis or inflammation, respectively. Here we report the identification of a novel protein, CARDINAL, that contains a CARD motif and also exhibits a high degree of homology to the C terminus of DEFCAP/NAC, a recently described member of the Apaf-1/Nod-1 family. In contrast with the majority of CARD proteins described to date… CONTINUE READING
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9230–9238 CARDINAL Is an Inhibitor of NF-"B Activation 44077 at IR eL (Trinity C olege D ulin), on Jauary 23

  • T. Hlaing, R. F. Guo, +5 authors P. A. Ward
  • J. Biol. Chem
  • 2001
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