CARD9 is a novel caspase recruitment domain-containing protein that interacts with BCL10/CLAP and activates NF-kappa B.

@article{Bertin2000CARD9IA,
  title={CARD9 is a novel caspase recruitment domain-containing protein that interacts with BCL10/CLAP and activates NF-kappa B.},
  author={John Bertin and Yin Guo and L Wang and Srinivasa M. Srinivasula and Matthew D. Jacobson and J L Poyet and Sarah Merriam and Ming Qin Du and Martin J S Dyer and K E Robison and Peter S Distefano and Emad S. Alnemri},
  journal={The Journal of biological chemistry},
  year={2000},
  volume={275 52},
  pages={41082-6}
}
BCL10/CLAP is an activator of apoptosis and NF-kappaB signaling pathways and has been implicated in B cell lymphomas of mucosa-associated lymphoid tissue. Although its role in apoptosis remains to be determined, BCL10 likely activates NF-kappaB through the IKK complex in response to upstream stimuli. The N-terminal caspase recruitment domain (CARD) of BCL10 has been proposed to function as an activation domain that mediates homophilic interactions with an upstream CARD-containing NF-kappaB… CONTINUE READING
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