CARD6 is interferon inducible but not involved in nucleotide-binding oligomerization domain protein signaling leading to NF-kappaB activation.

@article{Dufner2008CARD6II,
  title={CARD6 is interferon inducible but not involved in nucleotide-binding oligomerization domain protein signaling leading to NF-kappaB activation.},
  author={Almut Dufner and Gordon S. Duncan and Andrew C. Wakeham and Alisha R. Elford and H{\aa}kan T L Hall and Pamela S Ohashi and Tak W Mak},
  journal={Molecular and cellular biology},
  year={2008},
  volume={28 5},
  pages={1541-52}
}
We have previously reported the cloning and characterization of CARD6, a caspase recruitment domain (CARD)-containing protein that is structurally related to the interferon (IFN)-inducible GTPases. CARD6 associates with microtubules and with receptor-interacting protein 2 (RIP2). RIP2 mediates NF-kappaB activation induced by the intracellular nucleotide-binding oligomerization domain (NOD) receptors that sense bacterial peptidoglycan. Here we report that the expression of CARD6 and RIP2 in bone… CONTINUE READING

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