CARD15 gene mutations in sarcoidosis.

  title={CARD15 gene mutations in sarcoidosis.},
  author={Manfred Schuermann and Ruta Valentonyte and Jochen Hampe and Joachim Mueller-Quernheim and Eberhard Schwinger and Stefan Schreiber},
  journal={The European respiratory journal},
  volume={22 5},
Sarcoidosis, Blau syndrome and Crohn's disease are complex disorders, characterised by granulomatous inflammation affecting a variety of organs. Mutations of the CARD15 gene, on chromosome 16, have been shown to contribute significantly to Crohn's disease and to cause Blau syndrome. These factors prompted the current authors to study CARD15 mutations in sarcoidosis. A total of 138 families were genotyped, including 302 patients with sarcoidosis and 127 patients without a family history of… CONTINUE READING


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