CAR- or αv integrin-binding ablated adenovirus vectors, but not fiber-modified vectors containing RGD peptide, do not change the systemic gene transfer properties in mice

@article{Mizuguchi2002CARO,
  title={CAR- or αv integrin-binding ablated adenovirus vectors, but not fiber-modified vectors containing RGD peptide, do not change the systemic gene transfer properties in mice},
  author={Hiroyuki Mizuguchi and Naoya Koizumi and Tetsuji Hosono and Akiko Ishii-Watabe and Emi Uchida and Naoki Utoguchi and Yoshiteru Watanabe and Takao Hayakawa},
  journal={Gene Therapy},
  year={2002},
  volume={9},
  pages={769-776}
}
Targeted gene delivery to the tissue of interest by recombinant adenovirus (Ad) vectors is limited by the relatively broad expression of the primary receptor, the coxsackievirus and adenovirus receptor (CAR), and the secondary receptor, αv integrin. This problem could be overcome by mutating the fiber and penton base, which bind with CAR and αv integrin, respectively. In this study, we constructed CAR-binding ablated Ad vectors and αv integrin-binding ablated Ad vectors by mutation in the FG… CONTINUE READING

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