CAR/FoxP3-engineered T regulatory cells target the CNS and suppress EAE upon intranasal delivery

  title={CAR/FoxP3-engineered T regulatory cells target the CNS and suppress EAE upon intranasal delivery},
  author={Moa E. Fransson and Elena Piras and Joachim Burman and Berith Nilsson and Magnus Essand and Binfeng Lu and Robert A. Harris and Peetra U Magnusson and Eva B. Brittebo and Angelica Loskog},
  booktitle={Journal of Neuroinflammation},
Multiple sclerosis (MS) is an autoimmune disease of the central nervous system (CNS). In the murine experimental autoimmune encephalomyelitis (EAE) model of MS, T regulatory (Treg) cell therapy has proved to be beneficial, but generation of stable CNS-targeting Tregs needs further development. Here, we propose gene engineering to achieve CNS-targeting Tregs from naïve CD4 cells and demonstrate their efficacy in the EAE model. CD4+ T cells were modified utilizing a lentiviral vector system to… CONTINUE READING
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Loskog A: T regulatory cells lacking CD25 are increased in MS during relapse

  • M Fransson, J Burmna, C Lindqvist, C Atterby, J Fagius
  • Autoimmunity
  • 2010
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