CAR, the continuously advancing receptor, in drug metabolism and disease.

@article{Qatanani2005CARTC,
  title={CAR, the continuously advancing receptor, in drug metabolism and disease.},
  author={Mohammed Qatanani and David D. Moore},
  journal={Current drug metabolism},
  year={2005},
  volume={6 4},
  pages={
          329-39
        }
}
The detoxification and elimination of potentially toxic foreign and endogenous compounds depends on the concerted action of xenobiotic metabolizing enzymes. Nuclear hormone receptors (NHRs) have emerged as key regulators of the expression of these enzymes and his review focuses on the xenosenor CAR (Constitutive Androstane Receptor, NR1I3). CAR is highly expressed in the liver and the small intestine, two key tissues expressing xenobiotic metabolizing enzymes, and mediates the induction of… CONTINUE READING
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