CAPON modulates cardiac repolarization via neuronal nitric oxide synthase signaling in the heart.

@article{Chang2008CAPONMC,
  title={CAPON modulates cardiac repolarization via neuronal nitric oxide synthase signaling in the heart.},
  author={Kuan-Cheng Chang and Andreas S. Barth and Tetsuo Sasano and Eddy Kizana and Yuji Kashiwakura and Yiqiang Zhang and D. Brian Foster and Eduardo Marb{\'a}n},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2008},
  volume={105 11},
  pages={4477-82}
}
Congenital long- or short-QT syndrome may lead to life-threatening ventricular tachycardia and sudden cardiac death. Apart from the rare disease-causing mutations, common genetic variants in CAPON, a neuronal nitric oxide synthase (NOS1) regulator, have recently been associated with QT interval variations in a human whole-genome association study. CAPON had been unsuspected of playing a role in cardiac repolarization; indeed, its physiological role in the heart (if any) is unknown. To define… CONTINUE READING

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