CAPE (caffeic acid phenethyl ester)‐based propolis extract (Bio 30) suppresses the growth of human neurofibromatosis (NF) tumor xenografts in mice

@article{Demestre2009CAPEA,
  title={CAPE (caffeic acid phenethyl ester)‐based propolis extract (Bio 30) suppresses the growth of human neurofibromatosis (NF) tumor xenografts in mice},
  author={Maria Demestre and Shanta M. Messerli and Nicolas Luca Celli and Mona Shahhossini and Lan Kluwe and Victor Felix Mautner and Hiroshi Maruta},
  journal={Phytotherapy Research},
  year={2009},
  volume={23}
}
Dysfunction of the NF1 gene coding a RAS GAP is the major cause of neurofibromatosis type 1 (NF1), whereas neurofibromatosis type 2 (NF2) is caused primarily by dysfunction of the NF2 gene product called merlin that inhibits directly PAK1, an oncogenic Rac/CDC42‐dependent Ser/Thr kinase. It was demonstrated previously that PAK1 is essential for the growth of both NF1 and NF2 tumors. Thus, several anti‐PAK1 drugs, including FK228 and CEP‐1347, are being developed for the treatment of NF tumors… 
Artepillin C (ARC) in Brazilian green propolis selectively blocks oncogenic PAK1 signaling and suppresses the growth of NF tumors in mice
TLDR
It was confirmed that ARC as well as GPE suppress almost completely the growth of human NF tumor xenografts in mice, as does Bio 30, suggesting that both CAPE‐based and ARC‐based propolis extracts are natural anti‐PAK1 remedies and could be among the first effective NF therapeutics available on the market.
Propolis Extracts Two Distinct Propolis Extracts , Bio 30 from NZ and GPE from Brazil , Share a Common Biological Property : Blocking the Oncogenic PAK 1 Signaling to Suppress the Growth of NF Tumor Xenografts in Mice
TLDR
It is presented that the extracts from at least two vastly distinct propolis sources, CAPE (caffeic acid phenethyl ester)-based extract of NZ (New Zealand) propolis (Bio 30) and ARC (artepillin C)- based extract of Brazilian green propoli (GPE), share a very unique common property that inactivates selectively the oncogenic PAK1 signaling by their major anti-cancer ingredients, CAPe and ARC, respectively.
Molecular Characterization and Enhancement of Anticancer Activity of Caffeic Acid Phenethyl Ester by γ Cyclodextrin
TLDR
It is shown that whereas CAPE was unstable in the culture medium, its complex with gamma cyclodextrin (γCD) showed high efficacy in anti-tumor and anti-metastasis assays in vitro and in vivo (when administered through either intraperitoneal or oral route).
Artepillin C and Other Herbal PAK1‐blockers: Effects on Hair Cell Proliferation and Related PAK1‐dependent Biological Function in Cell Culture
TLDR
Among these herbal PAK1‐inhibitors, cucurbitacin I from bitter melon (Goya) turned out to be the most potent to inhibit the growth of human lung cancer cells with the IC50 around 140 nM and to promote the growth with the effective dose around 10‬nM.
Catechols in caffeic acid phenethyl ester are essential for inhibition of TNF-mediated IP-10 expression through NF-κB-dependent but HO-1- and p38-independent mechanisms in mouse intestinal epithelial cells.
TLDR
It is found that CAPE did not inhibit TNF-induced IκB phosphorylation/degradation or nuclear translocation of RelA/p65, but targeted downstream signaling events at the level of transcription factor recruitment to the gene promoter.
Caffeic acid phenethyl ester (CAPE) possesses pro-hypoxia and anti-stress activities: bioinformatics and experimental evidences
TLDR
Experimental evidence is provided that the low doses of CAPE activated HIF-1α and inhibited stress-induced protein aggregation, a common cause of age-related pathologies.
Caffeic acid phenethyl ester (CAPE) revisited: Covalent modulation of XPO1/CRM1 activities and implication for its mechanism of action
TLDR
The cellular mechanism underlying the diverse biological effects of CAPE, the bioactive constituent of propolis from honeybee hives, is revisited and it is demonstrated that XPO1/CRM1, a major nuclear export receptor, is a cellular target ofCAPE.
Caffeic acid phenethyl ester suppresses melanoma tumor growth by inhibiting PI3K/AKT/XIAP pathway.
TLDR
The results suggest that caffeic acid phenethyl ester suppresses phosphoinositide 3-kinase/AKT/XIAP pathway leading to apoptosis in melanoma tumor cells in vitro and in vivo.
Caffeic acid phenethyl ester, a major component of propolis, suppresses high fat diet-induced obesity through inhibiting adipogenesis at the mitotic clonal expansion stage.
TLDR
Results suggest that CAPE exerts an antiobesity effect in vivo, presumably through inhibiting adipogenesis at an early stage of adipogenesis.
Combination of Withaferin-A and CAPE Provides Superior Anticancer Potency: Bioinformatics and Experimental Evidence to Their Molecular Targets and Mechanism of Action
TLDR
Experimental evidences are provided that Wi-A and CAPE cause inactivation of PARP1-mediated DNA repair leading to accumulation of DNA damage and activation of apoptosis signaling by multiple ways, and a combination of Wi- A andCAPE offers selective toxicity and better potency to cancer cells.
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