CANADINE SYNTHASE FROM THALICTRUM TUBEROSUM CELL CULTURES CATALYSES THE FORMATION OF THE METHYLENEDIOXY BRIDGE IN BERBERINE SYNTHESIS

@article{Rueffer1994CANADINESF,
  title={CANADINE SYNTHASE FROM THALICTRUM TUBEROSUM CELL CULTURES CATALYSES THE FORMATION OF THE METHYLENEDIOXY BRIDGE IN BERBERINE SYNTHESIS},
  author={Martina Rueffer and Meinhart H. Zenk},
  journal={Phytochemistry},
  year={1994},
  volume={36},
  pages={1219-1223}
}
An enzyme system catalysing the formation of the methylenedioxy bridge at ring A of (S)-canadine [ = (S)-tetrahydroberberine] from (S)-tetrahydrocolumbamine has been detected in microsomal preparations from different Ranunculaceae and Berberidaceae cell cultures. The cytochrome P-450 enzyme complex has been partly characterized from a protoberberine alkaloid producing Thalictrum tuberosum L. cell line. The enzyme complex consisting of a microsomal associated oxidase with a cytochrome P-450… Expand

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