CAMs and Igs: Cell Adhesion and the Evolutionary Origins of Immunity

  title={CAMs and Igs: Cell Adhesion and the Evolutionary Origins of Immunity},
  author={Gerald M. Edelman},
  journal={Immunological Reviews},
  • G. Edelman
  • Published 1 December 1987
  • Biology
  • Immunological Reviews
The lymphoid system and cells of immunity are as morphologically well defined as those of any complex organ but in addition they show dynamic long-range interactions between the fluid tissues (lymphocytes, monocytes, etc.) and the solid, vascular and generative tissues and organs which they comprise. Given the observation that CAMs are present in epithelial components of lymphoid organs, it appears that, in their ontogeny, the organs of immunity will share a common principle of morphoregulation… 

Development of an Immune System a

It now appears that the recombination mechanisms essential for the anticipatory immune response occurred late in the deuterostome stream leading to vertebrates, molecules required for cell adhesion and regulation are widely spread in phylogeny.

Cellular signaling by neural cell adhesion molecules of the immunoglobulin superfamily

  • K. CrossinL. Krushel
  • Biology
    Developmental dynamics : an official publication of the American Association of Anatomists
  • 2000
This review focuses on the two CAMs for which the most information is known, the neural CAM, N‐CAM, and L1, and examines their interaction with cytoskeletal molecules.


  • M. L. Turner
  • Biology
    Biological reviews of the Cambridge Philosophical Society
  • 1992
The pathophysiology of processes such as infection and neoplasia are profoundly affected by cellular CAM expression, and CAMs and related molecules are fundamental to the development, maintenance and surveillance of tissue structure.

Cell and SubstrateAdhesion Moleculesin Embryonicand Neural Development

The increasing evidence for the hypothesis that CAMs and SAMs are excellent candidates for the genetic regulation of patterns during the development of the early embryo and of the nervous system is reviewed.

Morphoregulatory molecules and selectional dynamics during development.

  • K. Crossin
  • Biology
    International review of neurobiology
  • 1994

Modification of accessory molecule signaling

  • M. Crow
  • Biology, Medicine
    Springer Seminars in Immunopathology
  • 2006
Significantly for patients with autoimmune diseases, the manipulation of costimulatory signals represents a rational and effective approach to modulating the chronic immune system activation that characterizes those diseases.

Cell-CAM 105-an adhesive cell surface glycoprotein

Immunochemical and immunohistochemical investigations have shown that cellCAM 105 occurs in liver, several epithelia, vessel endothelia and platelets and polymorphonuclear leukocytes, and that it is expressed primarily in terminally differentiated cells or cells that are undergoing terminal differentiation.

Isolation And Characterisation Of Immunoglobulin Gene Superfamily Molecules From Lower Vertebrates (Fish)

The aim of this thesis was to use the polymerase chain reaction (PCR) in conjunction with degenerative primers to the T CR p chain variable region (TCRBV) sequences of the homed shark to allow the amplification of the TCR-Iike genes from dogfish, Scy/iorhinus canicula.

Thyroxine-dependent modulations of the expression of the neural cell adhesion molecule N-CAM during Xenopus laevis metamorphosis.

This work has studied by immunohistofluorescence and immunoblots the patterns of expression of N-CAM at different stages of Xenopus laevis metamorphosis, thought to play a central role in the control of morphogenetic processes.



Surface molecules and cell interactions.

LFA-1 and other accessory molecules functioning in adhesions of T and B lymphocytes.

Expression sequences of cell adhesion molecules.

A reexamination of the expression of cell adhesion molecules (CAMs) during the development of the chicken embryo was carried out using more sensitive immunocytochemical techniques than had been used previously, and it was found that cell surface modulation of the primary CAMs at induction sites can be classified into two modes.

Neural cell adhesion molecule: structure, immunoglobulin-like domains, cell surface modulation, and alternative RNA splicing.

The complete amino Acid sequences of the three major polypeptides of N-CAM and most of the noncoding sequences of their messenger RNA's were determined from the analysis of complementary DNA clones and were verified by amino acid sequences of selected CNBr fragments and proteolytic fragments.

The Origin of the Immune System

It appears that the Ig superfamily of the immune system originated from more ubiquitous ceil recognition moleeules whieh are eommon in all metazoan species.

Epigenetic rules for expression of cell adhesion molecules during morphogenesis.

The existence of the epigenetic rules governing CAM expression reflects the evolutionary conservation of a key means of establishing tissue and animal form through the mechanochemical regulation of processes such as cell division, movement and death.

Cell adhesion and morphogenesis: the regulator hypothesis.

  • G. Edelman
  • Biology
    Proceedings of the National Academy of Sciences of the United States of America
  • 1984
It is proposed that, during evolution, natural selection eliminates those organisms in which variants of CAM gene expression or of morphogenetic movements or of both result in interruptions in the inductive sequence.

Kinetics of homophilic binding by embryonic and adult forms of the neural cell adhesion molecule.

  • S. HoffmanG. Edelman
  • Biology
    Proceedings of the National Academy of Sciences of the United States of America
  • 1983
The results in a model system demonstrate the large range of binding rates that are obtainable by various forms of local surface modulation of N-CAM, consistent with the proposal that similar alterations affecting (N-C AM)-mediated cell adhesion in vivo may be major factors in pattern formation during development of the nervous system.

Evolutionary conservation of key structures and binding functions of neural cell adhesion molecules.

Results suggest that, in accord with the proposed role of N-CAM as a regulator of morphogenesis, both the specificity of the binding region of the molecule and its basic chemical structure have been highly conserved during evolution.