CAMPATH-IH in multiple sclerosis.

  title={CAMPATH-IH in multiple sclerosis.},
  author={Thibault Moreau and Alasdair Coles and Mark Wing and J. A. Thorpe and David Miller and Ivan Moseley and John T. Issacs and Geoffrey Hale and Donna Clayton and Neil J. Scolding and Herman Waldmann and Alastair D Compston},
  journal={Multiple sclerosis},
  volume={1 6},
In a pilot study, seven patients with multiple sclerosis were treated with CAMPATH-IH which targets the CD52 antigen present on lymphocytes and monocytes. There was a substantial reduction in disease activity as measured by gadoliunium-enhancing lesions on MRI. Encouraged by this result a further seven patients have been treated with CAMPATH-IH; four also received anti-CD4 antibody. Lymphopaenia developed rapidly and was sustained for at least one year. In 12 patients, the first infusion of… CONTINUE READING

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