CAMK4 gene variation is associated with hypertension in a Uygur population.

@article{Chen2016CAMK4GV,
  title={CAMK4 gene variation is associated with hypertension in a Uygur population.},
  author={S Z Chen and Z. Wang and L. N. Zhang and Guilin Lu and C. Zhou and D. W. Wang and Z Tang and L. Wang and Lian Qin and Zhihong Zhai},
  journal={Genetics and molecular research : GMR},
  year={2016},
  volume={15 1}
}
  • S. Chen, Z. Wang, +7 authors Z. Zhai
  • Published 22 January 2016
  • Biology, Medicine
  • Genetics and molecular research : GMR
Considering that calcium/calmodulin-dependent kinase 4 (CAMK4) plays a pivotal role in blood pressure regulation, we investigated the association between a CAMK4 polymorphism (rs10491334) and hypertension in the Han, Kazak, and Uygur ethnic groups. We studied 1224 patients with hypertension and 967 normotensive controls classified into three ethnic groups (Han, Kazak, and Uygur). The rs10491334 polymorphism was genotyped using a TaqMan® 5'-nuclease assay. In the Uygur group, the T-allele… 
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TLDR
Evidence is provided that CaMKIV plays a pivotal role in blood pressure regulation through the control of endothelial nitric oxide synthase activity and that the rs10491334 variant associates with a reduction in the expression levels in lymphocytes from hypertensive patients.
A common missense single nucleotide polymorphism in the E-selectin gene is significantly associated with essential hypertension in the Han population but only weakly associated in the Uygur population
TLDR
The results indicate that the common variant rs5361 is strongly associated with EH in Han individuals and weakly associated in Uygur individuals.
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TLDR
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TLDR
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TLDR
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TLDR
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TLDR
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