CALML5 is a ZNF750- and TINCR-induced protein that binds stratifin to regulate epidermal differentiation.

@article{Sun2015CALML5IA,
  title={CALML5 is a ZNF750- and TINCR-induced protein that binds stratifin to regulate epidermal differentiation.},
  author={Bryan K. Sun and Lisa D. Boxer and Julia D. Ransohoff and Zurab Siprashvili and Kun Qu and Vanessa Lopez-Pajares and S Tyler Hollmig and Paul A. Khavari},
  journal={Genes & development},
  year={2015},
  volume={29 21},
  pages={2225-30}
}
Outward migration of epidermal progenitors occurs with induction of hundreds of differentiation genes, but the identities of all regulators required for this process are unknown. We used laser capture microdissection followed by RNA sequencing to identify calmodulin-like 5 (CALML5) as the most enriched gene in differentiating outer epidermis. CALML5 mRNA was up-regulated by the ZNF750 transcription factor and then stabilized by the long noncoding RNA TINCR. CALML5 knockout impaired… CONTINUE READING

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