CALHM1-Mediated ATP Release and Ciliary Beat Frequency Modulation in Nasal Epithelial Cells

@inproceedings{Workman2017CALHM1MediatedAR,
  title={CALHM1-Mediated ATP Release and Ciliary Beat Frequency Modulation in Nasal Epithelial Cells},
  author={Alan D Workman and Ryan M Carey and Bei Chuan Chen and Cecil James Saunders and Philippe Marambaud and Claire H. Mitchell and Michael G Tordoff and Robert J Lee and Noam A Cohen},
  booktitle={Scientific Reports},
  year={2017}
}
Mechanical stimulation of airway epithelial cells causes apical release of ATP, which increases ciliary beat frequency (CBF) and speeds up mucociliary clearance. The mechanisms responsible for this ATP release are poorly understood. CALHM1, a transmembrane protein with shared structural features to connexins and pannexins, has been implicated in ATP release from taste buds, but it has not been evaluated for a functional role in the airway. In the present study, Calhm1 knockout, Panx1 knockout… CONTINUE READING
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