CAKβ/Pyk2 Kinase Is a Signaling Link for Induction of Long-Term Potentiation in CA1 Hippocampus

  title={CAKβ/Pyk2 Kinase Is a Signaling Link for Induction of Long-Term Potentiation in CA1 Hippocampus},
  author={Yue-Qiao Huang and Wei-yang Lu and Declan William Ali and Kenneth A. Pelkey and Graham M. Pitcher and You Ming Lu and Hiroshi Aoto and John C. C. Roder and Terukatsu Sasaki and Michael W. Salter and John F. MacDonald},
Long-term potentiation (LTP) is an activity-dependent enhancement of synaptic efficacy, considered a model of learning and memory. The biochemical cascade producing LTP requires activation of Src, which upregulates the function of NMDA receptors (NMDARs), but how Src becomes activated is unknown. Here, we show that the focal adhesion kinase CAKbeta/Pyk2 upregulated NMDAR function by activating Src in CA1 hippocampal neurons. Induction of LTP was prevented by blocking CAKbeta/Pyk2, and… CONTINUE READING
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