CAG repeats containing CAA interruptions form branched hairpin structures in spinocerebellar ataxia type 2 transcripts.

@article{Sobczak2005CAGRC,
  title={CAG repeats containing CAA interruptions form branched hairpin structures in spinocerebellar ataxia type 2 transcripts.},
  author={Krzysztof Sobczak and Wlodzimierz J. Krzyzosiak},
  journal={The Journal of biological chemistry},
  year={2005},
  volume={280 5},
  pages={3898-910}
}
Spinocerebellar ataxia type 2 (SCA2), one of the hereditary human neurodegenerative disorders, is caused by the expansion of the CAG tandem repeats in the translated sequence of the SCA2 gene. In a normal population the CAG repeat is polymorphic not only in length but also in the number and localization of its CAA interruptions. The aim of this study was to determine the structure of the repeat region in the normal and mutant SCA2 transcripts and to reveal the structural basis of its normal… CONTINUE READING

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